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Articles (55)
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Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression

Danielle R. Mercatante, Ryszard Kole

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Année:

2002

Langue:

english

Fichier:

PDF, 160 KB

english, 2002

Effects of Base Modifications on Antisense Properties of 2′- O -Methoxyethyl and PNA Oligonucleotides

Sazani, Peter, Astriab-Fischer, Anna, Kole, Ryszard

Journal:

Antisense and Nucleic Acid Drug Development

Année:

2003

Langue:

english

Fichier:

PDF, 2.30 MB

english, 2003

Exon skipping therapy for Duchenne muscular dystrophy

Kole, Ryszard, Krieg, Arthur M.

Journal:

Advanced Drug Delivery Reviews

Année:

2015

Langue:

english

Fichier:

PDF, 779 KB

english, 2015

Applications of the PMO platform to genetic diseases

Ryszard Kole

Journal:

Orphanet Journal of Rare Diseases

Année:

2015

Langue:

english

Fichier:

PDF, 256 KB

english, 2015

Spontaneous and MNNG-induced reversion of an EGFP construct in HeLa cells: An assay for observing mutations in living cells by fluorescent microscopy

Federica Gemignani, Stefano Landi, David M. DeMarini, Ryszard Kole

Journal:

Human Mutation

Année:

2001

Langue:

english

Fichier:

PDF, 457 KB

english, 2001

Modification of HER2 pre-mRNA alternative splicing and its effects on breast cancer cells

Jing Wan, Peter Sazani, Ryszard Kole

Journal:

International Journal of Cancer

Année:

2009

Langue:

english

Fichier:

PDF, 354 KB

english, 2009

Switching on transgene expression by correcting aberrant splicing using multi-targeting steric-blocking oligonucleotides

Sarah Resina, Ryszard Kole, Adrian Travo, Bernard Lebleu, Alain R. Thierry

Journal:

The Journal of Gene Medicine

Année:

2007

Langue:

english

Fichier:

PDF, 392 KB

english, 2007

RNA fingerprinting using a small horizontal agarose gel electrophoresis apparatus

Paul J. Furdon, Ryszard Kole

Journal:

Analytical Biochemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.01 MB

english, 1987

Short-term and long-term modulation of gene expression by antisense therapeutics

Peter Sazani, Marla M Vacek, Ryszard Kole

Journal:

Current Opinion in Biotechnology

Année:

2002

Langue:

english

Fichier:

PDF, 64 KB

english, 2002

Mismatched single stranded antisense oligonucleotides can induce efficient dystrophin splice switching

Clayton T Fragall, Abbie M Adams, Russell D Johnsen, Ryszard Kole, Sue Fletcher, Steve D Wilton

Journal:

BMC Medical Genetics

Année:

2011

Langue:

english

Fichier:

PDF, 653 KB

english, 2011

Peptide-Morpholino Conjugate: A Promising Therapeutic for Duchenne Muscular Dystrophy

Hong M. Moulton, Bo Wu, Natee Jearawiriyapaisarn, Peter Sazani, Qi Long Lu, Ryszard Kole

Journal:

Annals of the New York Academy of Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 268 KB

english, 2009

10.1038/6960

Kole, Ryszard

Journal:

Nature Biotechnology

Année:

1999

Langue:

english

Fichier:

PDF, 112 KB

english, 1999

Systemically delivered antisense oligomers upregulate gene expression in mouse tissues

Sazani, Peter, Gemignani, Federica, Kang, Shin-Hong, Maier, Martin A., Manoharan, Muthiah, Persmark, Magnus, Bortner, Donna, Kole, Ryszard

Journal:

Nature Biotechnology

Année:

2002

Langue:

english

Fichier:

PDF, 996 KB

english, 2002

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

Kole, Ryszard, Krainer, Adrian R., Altman, Sidney

Journal:

Nature Reviews Drug Discovery

Année:

2012

Langue:

english

Fichier:

PDF, 847 KB

english, 2012

Pre-mRNA splicing as a target for antisense oligonucleotides

Ryszard Kole, Ram R. Shukla, Saghir Akhtar

Journal:

Advanced Drug Delivery Reviews

Année:

1991

Langue:

english

Fichier:

PDF, 1.14 MB

english, 1991

Modification of alternative splicing pathways as a potential approach to chemotherapy

Danielle Mercatante, Ryszard Kole

Journal:

Pharmacology & Therapeutics

Année:

2000

Langue:

english

Fichier:

PDF, 280 KB

english, 2000

RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds

Furdon, Paul J., Dominski, Zbigniew, Kole, Ryszard

Journal:

Nucleic Acids Research

Année:

1989

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1989

Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides

Stephen D Wilton, Frances Lloyd, Kylie Carville, Sue Fletcher, Kaite Honeyman, Sudhir Agrawal, Ryszard Kole

Journal:

Neuromuscular Disorders

Année:

1999

Langue:

english

Fichier:

PDF, 301 KB

english, 1999

Up-Regulation of Luciferase Gene Expression with Antisense Oligonucleotides: Implications and Applications in Functional Assay Development †

Kang, Shin-Hong, Cho, Moo-Jung, Kole, Ryszard

Journal:

Biochemistry

Année:

1998

Langue:

english

Fichier:

PDF, 143 KB

english, 1998

Properties of purified ribonuclease P from Escherichia coli

Kole, Ryszard, Altman, Sidney

Journal:

Biochemistry

Année:

1981

Langue:

english

Fichier:

PDF, 1.49 MB

english, 1981

E. coli RNAase P has a required RNA component in vivo

Kole, Ryszard, Baer, Madeline F., Stark, Benjamin C., Altman, Sidney

Journal:

Cell

Année:

1980

Langue:

english

Fichier:

PDF, 4.49 MB

english, 1980

Inhibition of Splicing but not Cleavage at the 5′Splice Site by Truncating Human β -globin Pre-mRNA

Paul J. Furdon and Ryszard Kole

Journal:

Proceedings of the National Academy of Sciences

Année:

1986

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1986

Repair of Thalassemic Human β -globin mRNA in Mammalian Cells by Antisense Oligonucleotides

Halina Sierakowska, Maria J. Sambade, Sudhir Agrawal and Ryszard Kole

Journal:

Proceedings of the National Academy of Sciences

Année:

1996

Langue:

english

Fichier:

PDF, 1.38 MB

english, 1996

Stable Alteration of Pre-mRNA Splicing Patterns by Modified U7 Small Nuclear RNAs

Linda Gorman, Daniel Suter, Victoria Emerick, Daniel Schumperli and Ryszard Kole

Journal:

Proceedings of the National Academy of Sciences

Année:

1998

Langue:

english

Fichier:

PDF, 1.64 MB

english, 1998

Ribonuclease P: An Enzyme with an Essential RNA Component

Benjamin C. Stark, Ryszard Kole, Emma J. Bowman and Sidney Altman

Journal:

Proceedings of the National Academy of Sciences

Année:

1978

Langue:

english

Fichier:

PDF, 1.60 MB

english, 1978

Reconstitution of RNase P Activity from Inactive RNA and Protein

Ryszard Kole and Sidney Altman

Journal:

Proceedings of the National Academy of Sciences

Année:

1979

Langue:

english

Fichier:

PDF, 1.54 MB

english, 1979

Antisense 2′-O-Methyloligoribonucleotides Hybridized to RNA Block a Nuclear, ATP-Dependent 3′-5′ Exonuclease

DOMINSKI, ZBIGNIEW, FERREE, PATRICK, KOLE, RYSZARD

Journal:

Antisense and Nucleic Acid Drug Development

Année:

1996

Langue:

english

Fichier:

PDF, 14.88 MB

english, 1996

Analysis of Prostate-Specific Membrane Antigen Splice Variants in LNCap Cells

Williams, Tiffany, Kole, Ryszard

Journal:

Oligonucleotides

Année:

2006

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2006

Modification of Alternative Splicing by Antisense Therapeutics

Kole, Ryszard, Vacek, Marla, Williams, Tiffany

Journal:

Oligonucleotides

Année:

2004

Langue:

english

Fichier:

PDF, 313 KB

english, 2004

Therapeutic Potential of Splice-Switching Oligonucleotides

Bauman, John, Jearawiriyapaisarn, Natee, Kole, Ryszard

Journal:

Oligonucleotides

Année:

2009

Langue:

english

Fichier:

PDF, 393 KB

english, 2009

Restoration of ß-Globin Gene Expression in Mammalian Cells by Antisense Oligonucleotides That Modify the Aberrant Splicing Patierns of Thalassemic Pre-mRNAs

Sierakowska, Halina, Montague, Michael, Agrawal, Sudhir, Kole, Ryszard

Journal:

Nucleosides and Nucleotides

Année:

1997

Langue:

english

Fichier:

PDF, 793 KB

english, 1997

Delivery of Antisense Oligonucleotides and Plasmid DNA with Various Carrier Agents

KANG, SHIN-HONG, ZIRBES, ERIC LYNN, KOLE, RYSZARD

Journal:

Antisense and Nucleic Acid Drug Development

Année:

1999

Langue:

english

Fichier:

PDF, 1.59 MB

english, 1999

A System for Shuttling 200-kb BAC/PAC Clones into Human Cells: Stable Extrachromosomal Persistence and Long-Term Ectopic Gene Activation

Westphal, Eva Maria, Sierakowska, Halina, Livanos, Elisabeth, Kole, Ryszard, Vos, Jean-Michel

Journal:

Human Gene Therapy

Année:

1998

Langue:

english

Fichier:

PDF, 10.25 MB

english, 1998

89. Gene Targeting of β-Globin IVS2 Using Sequence-Specific Peptide Nucleic Acids

Kuan, Jean Y., Kole, Ryszard, Nielsen, Peter E., Glazer, Peter M.

Journal:

Molecular Therapy

Année:

2006

Langue:

english

Fichier:

PDF, 83 KB

english, 2006

Targeted Exon Skipping to Address “Leaky” Mutations in the Dystrophin Gene

Fletcher, Sue, Adkin, Carl F., Meloni, Penny, Wong, Brenda, Muntoni, Francesco, Kole, Ryszard, Fragall, Clayton, Greer, Kane, Johnsen, Russell, Wilton, Steve D.

Journal:

Molecular Therapy — Nucleic Acids

Année:

2012

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2012

Prevention of Dystrophic Pathology in Severely Affected Dystrophin/Utrophin-deficient Mice by Morpholino-oligomer-mediated Exon-skipping

Goyenvalle, Aurélie, Babbs, Arran, Powell, Dave, Kole, Ryszard, Fletcher, Sue, Wilton, Steve D, Davies, Kay E

Journal:

Molecular Therapy

Année:

2010

Langue:

english

Fichier:

PDF, 506 KB

english, 2010

Antisense derivatives of U7 and other small nuclear RNAs as tools to modify pre-mRNA splicing patterns

Asparuhova, Maria, Kole, Ryszard, Schumperli, Daniel

Journal:

Gene Therapy and Regulation

Année:

2004

Langue:

english

Fichier:

PDF, 1018 KB

english, 2004

Antibodies to hnRNP core proteins inhibit in vitro splicing of human β-globin pre-mRNA

Sierakowska, Halina, Szer, Wlodzimierz, Furdon, Paul J., Kole, Ryszard

Journal:

Nucleic Acids Research

Année:

1986

Langue:

english

Fichier:

PDF, 1.45 MB

english, 1986

Accurate in vitro splicing of human β-globin RNA

Kole, Ryszard, Weissman, Sherman M.

Journal:

Nucleic Acids Research

Année:

1982

Langue:

english

Fichier:

PDF, 2.50 MB

english, 1982

Sustained Dystrophin Expression Induced by Peptide-conjugated Morpholino Oligomers in the Muscles of mdx Mice

Jearawiriyapaisarn, Natee, Moulton, Hong M, Buckley, Brian, Roberts, Jennifer, Sazani, Peter, Fucharoen, Suthat, Iversen, Patrick L, Kole, Ryszard

Journal:

Molecular Therapy

Année:

2008

Langue:

english

Fichier:

PDF, 540 KB

english, 2008

An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models

Graziewicz, Maria A, Tarrant, Teresa K, Buckley, Brian, Roberts, Jennifer, Fulton, LeShara, Hansen, Henrik, Ørum, Henrik, Kole, Ryszard, Sazani, Peter

Journal:

Molecular Therapy

Année:

2008

Langue:

english

Fichier:

PDF, 397 KB

english, 2008

Superoxide-Dependent Iron Uptake

Ghio, Andrew J., Nozik-Grayck, Eva, Turi, Jennifer, Jaspers, Ilona, Mercatante, Danielle R., Kole, Ryszard, Piantadosi, Claude A.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Année:

2003

Fichier:

PDF, 282 KB

Kole, Ryszard

Année:

1982

Langue:

english

Fichier:

PDF, 901 KB

english, 1982